Description: Drugs for Constipation

DRUG	DRUG DESCRIPTION
Alvimopan	An opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel resection with primary anastomosis.
Bisacodyl	A stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults.
Bisoxatin	For use in the treatment of constipation in the absence of bowel obstruction and for surgical preparation of the colon .
Calcium polycarbophil	A bulk forming laxative used to treat constipation.
Castor oil	An ingredient used in a variety of natural health products.
Dantron	A drug used to relieve acute and chronic inflammation of the oral cavity and oropharynx.
Docusate	A medication used to treat constipation associated with dry, hard stools, or opioid induced constipation.
Elobixibat	Elobixibat has been used in trials studying the treatment and basic science of Dyslipidemia, Constipation, Chronic Constipation, Functional Constipation, and Chronic Idiopathic Constipation.
Glycerin	It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Karaya gum	An extract from Karaya gum used in allergy testing.
Lactitol	An orally administered osmotic laxative used to treat chronic idiopathic constipation.
Lactulose	A disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy.
Linaclotide	A guanylate cyclase-C agonist used to treat different types of constipation, such as irritable bowel syndrome-related constipation, idiopathic constipation, and functional constipation.
Lubiprostone	A prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
Magnesium carbonate	An antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
Magnesium citrate	A laxative used in bowel preparation for colonoscopy or as a magnesium supplement.
Magnesium oxide	A compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.
Magnesium peroxide	Not Annotated
Magnesium sulfate	A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
Mannitol	A sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.
Methylcellulose	A compound used as a bulk forming laxative and is not an approved medication.
Methylnaltrexone	A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
Mineral oil	Mineral oil is not considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indication. It is typically present in topical formulations as an emollient and occlusive…
Naldemedine	An opioid antagonist used to to treat opioid-induced constipation.
Naloxegol	A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
Naloxone	An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
Oxyphenisatin	A laxative that undergoes enterohepatic circulation. It may cause jaundice.
Pentaerithrityl	Not Annotated
Phenolphthalein	A drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures.
Picosulfuric acid	A stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.
Plantago ovata seed	A plant extract indicated in the treatment of occasional constipation.
Plecanatide	A laxative used to treat chronic idiopathic constipation and IBS with constipation.
Polyethylene glycol	A laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
Prucalopride	A 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation.
Sennosides	A laxative used to treat constipation.
Sodium lauryl sulfoacetate	A laxative indicated in the treatment of constipation and bowel preparation for rectal endoscopy.
Sodium phosphate, monobasic	A source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.
Sodium sulfate	An agent used for bowel cleansing prior to colonoscopy or barium enema X-ray examination.
Sodium tartrate	It acts as an emulsifier and pH control agent in food products , . In the laboratory, it is used while performing the Karl Fischer equation, which is used to…
Sorbitol	A product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
Tegaserod	A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
Tenapanor	An NHE3 inhibitor indicated for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic kidney disease,

Description: Drugs used to prevent nausea and vomiting

DRUG	DRUG DESCRIPTION
Alizapride	A dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies.
Alosetron	A 5-HT3 antagonist used to treat diarrhea-predominant IBS.
Amisulpride	A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults.
Aprepitant	A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
Azasetron	Not Annotated
Bromopride	A substituted benzamide, closely related to metoclopramide, used as an antiemetic.
Casopitant	Investigated for use/treatment in urinary incontinence and adverse effects (chemotherapy).
Chlorpromazine	A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
Clebopride	A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy.
Cyclizine	An antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo.
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
Dexanabinol	Investigated for use/treatment in traumatic brain injuries and neurologic disorders.
Dimenhydrinate	A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
Diphenidol	An antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere’s disease and surgery of the middle and inner ear.
Dixyrazine	Not Annotated
Dolasetron	An antinauseant and antiemetic used in chemotherapy and postoperatively.
Domperidone	A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting.
Doxylamine	An antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy.
Droperidol	A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
Fosaprepitant	An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy.
Granisetron	A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
Haloperidol	An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium.
Lorazepam	A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
Maropitant	Maropitant, used as maropitant citrate, is a neurokinin receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by…
Meclizine	A histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.
Methylprednisolone	A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
Metoclopramide	An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
Metopimazine	Not Annotated
Nabilone	A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
Olanzapine	An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
Ondansetron	A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
Palonosetron	A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
Peppermint oil	An ingredient used in a variety of natural health products and is not an approved medication.
Prochlorperazine	A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.
Promazine	A phenothiazine used to manage schizophrenia.
Ramosetron	A selective 5-HT3 antagonist used as an antiemetic for chemotherapy- and postoperative-associated nausea and vomiting. It may also possess efficacy in irritable bowel syndrome.
Scopolamine	A belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).
Thiethylperazine	A drug used for the treatment of nausea and vomiting.
Trifluoperazine	A phenothiazine used to treat depression, anxiety, and agitation.
Triflupromazine	Used mainly in the management of psychoses. Also used to control nausea and vomiting.
Trimethobenzamide	An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis.
Tropisetron	A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting.
Vofopitant	Vofopitant has been used in trials studying the treatment of PTSD, Primary Insomnia, and Sleep Initiation and Maintenance Disorders.