Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. It works by inactivating (H+/K+)-ATPase function in the stomach.
Indication:
- Treatment of stomach ulcers
- short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD)
- maintenance of healing of erosive esophagitis
- pathological hypersecretory conditions including Zollinger–Ellison syndrome.
- It may also be used along with other medications to eliminate Helicobacter pylori.
Effectiveness is similar to other proton pump inhibitors (PPIs). It is available by mouth and by injection into a vein.
Common side effects include headaches, diarrhea, vomiting, abdominal pain, and joint pain.
Serious side effects: may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridium difficile colitis, low magnesium, and vitamin B12 deficiency. Pregnancy: Use in pregnancy appears to be safe.