- G-CSF stimulates granulocyte production in BM suppressed by chemotherapy and radiotherapy and reduces infections in cancer patients. It can induce terminal maturation of myeloid leukemia cells, resulting in complete hematologic and cytologic remission, and can suppress self-renewal. It is useful in patients with AIDS or leukemic relapse after allogeneic BM transplantation.
- Indication: Prevention of febrile neutropenia and associated infection in patients who have received bone marrow–depressing antineoplastics for the treatment of non-myeloid malignancies.Reduction of time for neutrophil recovery and duration of fever in patients undergoing induction and consolidation chemotherapy for acute myelogenous leukemia.Reduction of time to neutrophil recovery and sequelae of neutropenia in patients with non-myeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation.Mobilization of hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis.Management of severe chronic neutropenia.Neutropenia is associated with HIV infection.Neonatal neutropenia.
Synonyms
G-CSF