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Bisoprolol, marketed under the tradename Zebeta among others, is a beta-blocker medication most commonly used for heart diseases. This specifically includes high blood pressure, chest pain from not enough blood flow to the heart, and heart failure. It is taken by mouth.

Common side effects include headache, feeling tired, diarrhea, and swelling in the legs. More severe side effects include worsening asthma, blocking the ability to recognize low blood sugar, and worsening heart failure. There are concerns that use during pregnancy may be harmful to the baby. Bisoprolol is in the beta-blocker family of medications and is of the β1 selective type.

Synonyms
Zebeta, Apo-Bisoprolol, Bisoprolol, Cardicor, Emcor, Emcor LS, Monocor, Novo-Bisoprolol (CA), PMS-Bisoprolol (CA), Sandoz Bisoprolol (CA), Zebeta