Dosing & Administration
Adult
Oral:
- Age-related macular degeneration (AMD): A standardized ginkgo leaf extract called EGb 761, 60-240 mg orally in two or three divided doses daily for 6 months, has been used. This extract is standardized to contain 5% to 7% terpene lactones and 22% to 27% ginkgo flavone glycosides. It is an ingredient of several commercial products, including Tanakan (Ipsen) and Tebonin forte (Schwabe).
- Altitude sickness: A standardized ginkgo leaf extract called EGb 761, 160 mg in two divided doses daily has been used. A different standardized ginkgo extract, 120 mg twice daily for 3-4 days prior to climbing and continuing for 1-2 days until reaching target altitude, has been used.
- Anxiety: A standardized ginkgo extract called EGb 761, 80 or 160 mg three times daily for 4 weeks, has been used.
- Cognitive function: Single doses of ginkgo extract 240-600 mg have been used. A standardized ginkgo extract called EGb 761, 120-240 mg taken once daily or in two or three divided doses daily for 4 weeks to 24 weeks, has been used. Another specific ginkgo extract called LI 1370 (Lichtwer Pharma), 120-300 mg daily in three divided doses for 2 days has been used. A specific combination product (Ginkoba M/E, Pharmaton SA) containing ginkgo extract (GK501, Pharmaton SA) 100-600 mg and Panax ginseng (G115, Pharmaton SA) 60-360 mg, taken as a single dose or once daily for 12 weeks, has been used . Also, two capsules of a product containing ginkgo extract 40 mg/capsule and Codonopsis 75 mg/capsule, have been used daily
- Dementia: A standardized ginkgo extract called EGb 761 120-240 mg (Dr. Willmar Schwabe Pharmaceuticals and Ipsen), taken once daily or in two or three divided doses daily for up to 7.3 years, has been used, Higher doses of ginkgo (240 mg) might have a greater effect than lower doses (120 mg) . A similar standardized ginkgo extract called LI 1370 (Lichtwer Pharma) has also been used. A combination product (Memo, Pharco Pharmaceuticals), which contains standardized ginkgo leaf extract 120 mg, royal jelly 750 mg, and standardized Panax ginseng root extract 150 mg for 4 weeks has been used.
- Diabetic retinopathy: A standardized ginkgo leaf extract called EGb 761 120 mg daily for 6 months has been used.
- Fibromyalgia: Ginkgo extract (Bio-Biloba, Pharma Nord) 200 mg daily in conjunction with coenzyme Q10 (Bio Quinone Q10, Pharma Nord) 200 mg daily for 84 days has been used.
- Gastric cancer: Carbohydrates from the outer layer of ginkgo fruit 250 mg twice daily for 30 days has been used.
- Glaucoma: Ginkgo leaf extract 120-160 mg, taken in two or three divided doses daily for up to 12.3 years, has been used.
- Hearing loss: Ginkgo leaf extract 120 mg twice daily for 8 weeks has been used.
- Migraine headache: A specific product (Migrasoll, Pharmaval Srl, Italy) containing ginkgolide B 60 mg, coenzyme Q10 11 mg, and vitamin B2 8.7 mg, twice daily for 4 months, has been used.
- Peripheral arterial disease (PAD): A standardized ginkgo extract called EGb 761 120-240 mg, taken once daily or in two divided doses daily for up to 6.1 years, has been used.
- Premenstrual syndrome (PMS): A specific ginkgo leaf extract (Ginko T.D., Tolidaru Pharmaceuticals), 40 mg three times daily beginning on the 16th day of a menstrual cycle and continuing until the 5th day of the next cycle, has been used. Another standardized ginkgo extract called EGb 761, 80 mg twice daily beginning on the 16th day of a menstrual cycle and continuing until the 5th day of the next cycle for two cycles, has been used.
- Quality of life: A standardized ginkgo extract called LI 1370, 120 mg daily for 4-10 months, has been used.
- Radiation exposure: A standardized gingko extract called EGb 761 (Tanakan, Ipsen) 120 mg daily for 2 months has been used.
- Raynaud syndrome: A standardized ginkgo extract (Seredrin, Health Perception Ltd.) 120 mg three times daily for 10 weeks has been used.
- Schizophrenia: A standardized ginkgo leaf extract called EGb 761 (Yi Kang Ning, Yang Zi Jiang Pharmaceuticals Ltd., Jiangsu, China), 120-360 mg daily for 8-16 weeks, has been used.
- Sexual dysfunction: A specific combination product (ArginMax for Women, The Daily Wellness Company) containing ginkgo leaf extract, Panax ginseng root extract, damiana leaf extract, L-arginine, multivitamins, and minerals, taken daily for 4 weeks, has been used.
- Tardive dyskinesia: A standardized ginkgo leaf extract called EGb 761, 80 mg three times daily for 12 weeks, has been used.
- Vertigo: A standardized ginkgo leaf extract called EGb 761, 160 mg taken once daily or in two divided doses daily for 3 months, has been used
- Vitiligo: A standardized ginkgo extract (Ginkgo Plus, Seroyal) 120 mg in two divided doses daily for up to 6 months has been used.
Intravenous/Intramuscular:
- Colorectal cancer: A standardized ginkgo extract called EGb 761 ONC, 350 mg administered intravenously over 30 minutes on days 1-6 of every 3-week cycle in combination with 5-fluorouracil 500 mg/m2 administered intravenously 30 minutes daily on days 2-6 of every 3-week cycle for 4 courses of treatment, has been used.
- Pancreatic cancer: A standardized ginkgo extract called EGb 761 ONC, 350 mg administered intravenously over 30 minutes on days 1-6 of every 3-week cycle in combination with 5-fluorouracil 500 mg/m2 administered intravenously 30 minutes daily on days 2-6 of every 3-week cycle until disease progression, has been used.
Topical:
- Allergic rhinitis: Two drops of a specific eye drop product (Trium, SOOFT, Italy) containing a combination of ginkgo extract 0.05% and hyaluronic acid 0.15%, applied to each eye three times daily for one month, has been used.
- Radiation dermatitis: A specific cream product (Radioskin 2), which contains ginkgo extract, Aloe vera, and metal esculetina, along with another specific cream product (Radioskin 1), which contains alga atlantica and ethylbisiminomethylguaicolo manganese cloruro, applied two to three times daily at least 3 hours before and after radiation treatment, beginning 15 days prior to radiation and continuing until one month after completion, has been used.
Children
Oral:
- Attention deficit-hyperactivity disorder (ADHD): A specific combination product (AD-fX, Afexa Life Sciences, Canada) containing American ginseng extract 200 mg plus ginkgo extract 50 mg twice daily for 4 weeks has been used in children ages 3 to 17 years. A standardized ginkgo extract (Ginko T.D., Tolidaru Pharmaceuticals) 80-120 mg daily for 6 weeks together with methylphenidate has been used in children ages 6 to 12 years.
- Dyslexia: A standardized ginkgo leaf extract called EGb 761 80 mg daily for an average of 34 days, has been used in children aged 5-16 years.
- Migraine headache: Combination formulations containing ginkgolide B (BN52021), a constituent of ginkgo extract, along with coenzyme Q10, riboflavin, and magnesium, administered twice daily for 3 months, have been used in school-aged children.