| Drug | Interacting Drug | Mechanism | Monitoring And Management | Comments |
|---|---|---|---|---|
| Warfarin | A. Antibiotics 1. Ciprofloxacin, Levofloxacin, Metronidazole 2. Rifampin B. Antiplatelet Drugs Aspirin, Clopidogrel (Plavix), Dipyridamole C. Other Blood Thinners Heparin or direct oral anticoagulants (DOACs) like rivaroxaban or apixaban D. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Ibuprofen, Naproxen E. Antifungal Drugs Fluconazole, Ketoconazole, and Itraconazole F. Antidepressants 1. SSRIs like Fluoxetine and Sertraline 2. TCAs like Amitriptyline G. Herbal Supplements Ginkgo biloba, Garlic, Ginger, Ginseng, and St. John's Wort H. Vitamin K-rich Foods Foods rich in Vitamin K (like leafy green vegetables, broccoli, and brussels sprouts) I. Anticonvulsants Phenytoin and Carbamazepine J. Other Medications 1. Amiodarone and Cimetidine 2. Amiodarone and Cimetidine | -------------- 1. Increase warfarin's effect, raising the risk of bleeding by reducing the liver's ability to metabolize warfarin. 2. Reduces the effectiveness of warfarin by increasing its metabolism in the liver -------------- Increase the risk of bleeding when taken with warfarin, as both interfere with platelet function -------------- Increases the risk of excessive bleeding -------------- NSAIDs can increase the risk of bleeding, especially gastrointestinal bleeding, by inhibiting platelet aggregation and irritating the stomach lining -------------- Increase warfarin levels in the blood, heightening the bleeding risk -------------- 1. May slightly increase the risk of bleeding, particularly when combined with warfarin 2. May also enhance warfarin’s effects -------------- Can interfere with warfarin, either enhancing or reducing its anticoagulant effect, leading to bleeding or clotting risks -------------- Can reduce the effectiveness of warfarin, as Vitamin K promotes clotting -------------- Can lower warfarin levels, potentially making it less effective -------------- 1. Can increase the effects of warfarin 2. Can alter warfarin's effectiveness by affecting metabolism | 1. Patients on warfarin require regular monitoring of their International Normalized Ratio (INR) to ensure the correct dosage and prevent complications. 2. Any new medications or supplements should be discussed with a healthcare provider to evaluate potential interactions with warfarin. | |
| Bisoprolol | ||||
| Labetalol | ||||
| Levofloxacin |
