Classical Hodgkin Lymphoma

Overview:

• B-cell lymphoma with Reed-Sternberg cells (CD15+, CD30+)
• Four subtypes: Nodular sclerosis, mixed cellularity, lymphocyte-rich, lymphocyte-depleted

Presentation:

Painless lymphadenopathy (often cervical), B symptoms, mediastinal mass

Treatment:

• ABVD or Brentuximab-based regimens
• ISRT in select cases (e.g., bulky disease)

Prognosis: High cure rate, especially in early-stage