Involved-Site Radiation Therapy (ISRT)

  • Definition: A modern, precise form of radiation targeting only initially involved lymph node regions with margins.
  • Use: Commonly used in early-stage Hodgkin lymphoma or bulky disease after chemotherapy.
  • Pros:
    • Reduces radiation exposure to healthy tissues
    • Lowers risk of long-term toxicities (e.g., secondary cancers, cardiotoxicity)
  • Pharmacist role:
    • Coordination of care with radiation oncology
    • Monitor for radiation-enhanced toxicities (e.g., mucositis if head/neck, fatigue)
Synonyms
Involved-Site Radiation Therapy , ISRT
Links