| ACE Inhibitor | Lisinopril | Zestril, Prinivil | BP, K+, Cr | Teratogenic, monitor renal | 0.07 mg/kg/day | ↓ dose if GFR <30 | Coversyl (perindopril), Ramipril |
| Alpha-2 Agonist | Clonidine | Catapres | BP, HR | Rebound HTN if stopped abruptly | 5–10 mcg/kg/day divided BID | Adjust in renal impairment | Guanfacine |
| Alpha-Blocker | Tamsulosin | Flomax | BP, LUTS | Orthostatic hypotension | Not approved | No adjustment | Alfuzosin, Doxazosin |
| Anticonvulsant | Valproic Acid | Depakote | LFTs, CBC, ammonia levels | Risk of hepatotoxicity; monitor for pancreatitis | 10–15 mg/kg/day divided BID/TID | No adjustment | Divalproex Sodium |
| Antidepressant (SSRI) | Fluoxetine | Prozac | Mood changes, weight | Long half-life; monitor for activation of mania | ≥8 years: 10–20 mg/day | No adjustment | Paroxetine, Citalopram |
| Antiepileptic | Levetiracetam | Keppra | Mood, Cr | Behavior issues | 10–60 mg/kg/day | ↓ dose if GFR <80 | Brivaracetam (Briviact) |
| Antiplatelet | Clopidogrel | Plavix | CBC, bleeding | Prodrug, CYP2C19 dependent | Not well established | No adjustment | Ticagrelor, Prasugrel |
| Antipsychotic (Atypical) | Quetiapine | Seroquel | Weight, glucose | Sedation, metabolic effects | 0.5–1 mg/kg/day | No adjustment | Olanzapine, Risperidone |
| Antiviral (Influenza) | Oseltamivir | Tamiflu | Renal function | Start within 48 hrs of onset | ≥2 weeks: 3 mg/kg/dose BID | ↓ dose if CrCl <60 | Zanamivir |
| Antibiotic (Fluoroquinolone) | Ciprofloxacin | Cipro | QTc, tendon pain | Avoid <18 y/o unless needed | 10–20 mg/kg/dose | ↓ dose if GFR <30 | Levofloxacin |
| Antibiotic (Macrolide) | Azithromycin | Zithromax | QTc, LFTs | Once-daily dosing | 10 mg/kg/day | No adjustment | Clarithromycin |
| Antibiotic (Penicillin) | Amoxicillin | Amoxil | Allergy, Cr | Rash common in EBV | 20–90 mg/kg/day | ↓ dose if GFR <30 | Trimox, Moxatag |
| Anticoagulant (DOAC) | Apixaban | Eliquis | Cr, bleeding | No INR needed | Not FDA approved | ↓ dose if CrCl <30 | Rivaroxaban, Dabigatran |
| Anticoagulant (VKA) | Warfarin | Coumadin | INR | Vitamin K diet interactions | 0.2 mg/kg/day | No adjustment | Jantoven |
| Antiemetic (5HT3 Blocker) | Ondansetron | Zofran | ECG | QT prolongation risk | 0.15 mg/kg/dose q8h | No adjustment | Granisetron, Dolasetron |
| Azole Antifungal | Fluconazole | Diflucan | LFTs, renal function | QT prolongation risk | 6–12 mg/kg/day | ↓ dose if CrCl <50 | Ketoconazole, Itraconazole |
| Beta-Blocker | Metoprolol | Lopressor, Toprol XL | BP, HR | May cause bradycardia; taper off slowly | 1–2 mg/kg/day divided BID | Adjust in severe renal impairment | Atenolol, Bisoprolol |
| Bronchodilator (SABA) | Albuterol | Ventolin, ProAir | HR, RR | May cause tachycardia | 0.15 mg/kg/dose q4–6h | No adjustment | Levalbuterol |
| CCB (DHP) | Amlodipine | Norvasc | BP, edema | Preferred in Black adults | 0.05–0.3 mg/kg/day | No adjustment | Felodipine, Nifedipine |
| CCB (non-DHP) | Diltiazem | Cardizem | HR, BP | Avoid in HFrEF | Not established | Use with caution | Verapamil |
| CNS Stimulant | Amphetamine/Dextroamphetamine | Adderall | BP, HR, growth | Potential for abuse; insomnia | ≥3 y/o: 2.5–5 mg/day | Use with caution | Methylphenidate |
| Corticosteroid | Prednisone | Deltasone | Glucose, BP | Taper if long use | 1–2 mg/kg/day | No adjustment | Methylprednisolone |
| Diuretic (Loop) | Furosemide | Lasix | Electrolytes | Monitor for ototoxicity | 1–2 mg/kg/dose | ↓ dose in renal failure | Bumetanide |
| Diuretic (Thiazide) | HCTZ | Microzide | K+, glucose | May ↑ uric acid | 1–2 mg/kg/day | Less effective if GFR <30 | Chlorthalidone |
| Fibrate | Fenofibrate | Tricor | Lipids, renal function | Risk of myopathy with statins | Not established | Avoid in severe renal impairment | Gemfibrozil |
| GLP-1 Receptor Agonist | Semaglutide | Ozempic | Weight, A1c | Weekly dosing, GI upset | Not approved | Not recommended | Liraglutide (Victoza) |
| H1 Antihistamine | Diphenhydramine | Benadryl | Sedation | Drowsiness, anticholinergic effects | 1 mg/kg/dose q6–8h | No adjustment | Hydroxyzine, Chlorpheniramine |
| LABA + ICS | Fluticasone + Salmeterol | Advair | Lung fxn, oral thrush | Rinse mouth after use | 1 inhalation BID (age-based) | No adjustment | Symbicort, Breo Ellipta |
| Long-acting Insulin | Insulin Glargine | Lantus | Glucose, weight | Hypoglycemia risk | 0.2–0.4 units/kg/day | Use cautiously | Basaglar, Toujeo |
| NSAID | Ibuprofen | Advil, Motrin | Cr, GI bleed | Take with food | 5–10 mg/kg/dose q6–8h | Avoid in GFR <30 | Naproxen, Ketoprofen |
| PPI | Omeprazole | Prilosec | Mg, B12 (long-term) | Use lowest effective dose | 1 mg/kg/day | No adjustment | Esomeprazole, Lansoprazole |
| PPI | Pantoprazole | Protonix | Mg, B12 (long-term) | Long-term use caution | ≥5 y/o: 20–40 mg/day | No adjustment | Omeprazole, Esomeprazole |
| Potassium-Sparing Diuretic | Spironolactone | Aldactone | K+, renal function | Risk of hyperkalemia | 1–3 mg/kg/day divided BID | Adjust in renal impairment | Eplerenone |
| SNRI | Duloxetine | Cymbalta | BP, LFTs | Avoid in hepatic disease | Not approved <7 y/o | Avoid if CrCl <30 | Venlafaxine |
| SGLT2 Inhibitor | Empagliflozin | Jardiance | BP, ketones | Risk of DKA, UTI | Not approved <10 y/o | Avoid if GFR <30 | Dapagliflozin (Farxiga) |
| SSRI | Sertraline | Zoloft | Na+, mood | Suicidality risk | 1–2 mg/kg/day | No adjustment | Fluoxetine, Escitalopram |
| Statin | Atorvastatin | Lipitor | LFTs, lipids | Myopathy risk | ≥10 y/o: 10–20 mg/day | No adjustment | Rosuvastatin, Simvastatin |
| Sulfonylurea | Glipizide | Glucotrol | Blood glucose, HbA1c | Risk of hypoglycemia; caution in elderly | Not recommended | Caution in renal impairment | Glyburide, Glimepiride |
| Thyroid Hormone | Levothyroxine | Synthroid | TSH, free T4 | Administer on empty stomach | 10–15 mcg/kg/day | No adjustment | Euthyrox, Eltroxin |
| Typical Antipsychotic | Haloperidol | Haldol | ECG, EPS | High EPS risk | 0.05–0.15 mg/kg/day BID/TID | Adjust in renal impairment | Chlorpromazine |
