CD33 is a cell surface receptor primarily found on myeloid cells (monocytes, granulocytes, dendritic cells) and leukemic blasts in ~90% of AML cases.
- Function:
- Modulates immune responses via inhibitory signaling.
- Role in cell adhesion and apoptosis regulation.
- Clinical Relevance:
- Therapeutic target for gemtuzumab ozogamicin (anti-CD33 ADC) in AML.
- Biomarker tested by flow cytometry (≥20% blast expression defines CD33+ AML).