Astrocytoma (Pediatric)

Definition:

• Tumor derived from astrocytes. Includes low-grade (pilocytic) and high-grade (anaplastic/glioblastoma) variants.

Epidemiology:

• Most common benign/low-grade pediatric brain tumor.
• Peak incidence: 5–10 years.

Location:

• Often cerebellum (posterior fossa) for low-grade
• High-grade may occur in supratentorial region.

Clinical Features:

• Headache, vomiting, visual changes
• Seizures possible if supratentorial

Treatment & Pharmacist Role:

1. Surgery – resection often curative for low-grade.
2. Radiotherapy – for high-grade or residual disease.
3. Chemotherapy – mainly for inoperable or recurrent tumors:
   • Carboplatin, vincristine, temozolomide.
   • Monitor for myelosuppression, neuropathy, renal function.

Pharmacist Notes:

• Low-grade tumors may require minimal chemo, so supportive care focus.
• High-grade tumors require aggressive chemo-radiation, monitoring for toxicity and neurocognitive late effects.