Rituximab + Cyclophosphamide, Doxorubicin, Vincristine, Prednisone
Used for:
- Aggressive NHL (e.g., DLBCL)
- Sometimes used for Grade 3b follicular lymphoma
Dosing (Every 21 days, x 6 cycles typical):
- Rituximab 375 mg/m² IV Day 1
- Cyclophosphamide 750 mg/m² IV Day 1
- Doxorubicin 50 mg/m² IV Day 1
- Vincristine 1.4 mg/m² (max 2 mg) IV Day 1
- Prednisone 100 mg PO Days 1–5
Key Toxicities:
- Myelosuppression
- Cardiotoxicity (doxorubicin)
- Peripheral neuropathy (vincristine)
- Infusion reactions, tumor lysis
- GI toxicity, alopecia
- Steroid side effects: insomnia, hyperglycemia