Perimenopausal: Transitional phase leading up to menopause, where ovarian function is irregular but not fully ceased.
- Oncology relevance:
- Hormone levels fluctuate, affecting breast cancer risk and tumor biology.
- Endocrine therapy may need adjustment; ovarian suppression might be considered if hormone receptor–positive.
- Pharmacist note: Important to assess menstrual status and hormone levels when selecting tamoxifen vs aromatase inhibitor ± ovarian suppression.