High-Dose Interleukin-2

  • Class: Cytokine immunotherapy
  • Mechanism: Stimulates proliferation and activation of T cells and NK cells
  • Indications:
  • Dose:
    • IV bolus dosing (e.g., 600,000 IU/kg every 8 hours up to 14 doses per cycle)
    • Requires inpatient administration due to toxicity
  • Key Toxicities:
    • Capillary leak syndrome → hypotension, edema, organ dysfunction
    • Renal dysfunction, arrhythmias, mental status changes
    • Requires ICU-level monitoring
  • Monitoring:
    • Cardiac, renal, fluid balance, infection signs, mental status
    • Supportive care critical