Fibrinogen is a soluble plasma protein made by the liver that plays a critical role in blood clotting (coagulation).
🧬 Function:
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During blood clotting, the enzyme thrombin converts fibrinogen into fibrin.
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Fibrin forms insoluble strands that weave through the clot, helping to seal wounds and stop bleeding.
🔍 Clinical Importance:
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Low fibrinogen (hypofibrinogenemia):
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Can lead to bleeding problems.
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Seen in conditions like disseminated intravascular coagulation (DIC), liver disease, or inherited disorders.
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High fibrinogen:
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Acts as an acute-phase reactant, so levels can increase with inflammation, infection, or chronic diseases.
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High levels are also considered a risk factor for cardiovascular disease.
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🧪 Normal Blood Level:
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Typically 200–400 mg/dL in adults